Pagoclone online kaufen

Pagoclone online kaufen

Description of the

Buy PagoclonePagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other better-known drugs such as the sleeping pill zopiclone. It belongs to a relatively newly developed class of drugs known as non-benzodiazepines, which have similar effects to the older group of benzodiazepines but have a completely different chemical structure.

Synthesis analysis

The synthesis of pagoclones involves the reaction of 2-amino-7-chloro-1,8-naphthyridine with phthalic anhydride, which leads to the corresponding phthalimide. A selective reduction of one of the imide carbonyl groups yields the corresponding alcohol.

Analysing chemical reactions

Pagoklon is a subtype-selective drug that binds primarily to the alpha2/alpha3 subtypes of the GABAA receptor. These receptors are responsible for the anxiolytic effects of this type of medication. Chemsman

Analysing physical and chemical properties

Pagoklon ist ein kleines Molekül mit der chemischen Formel C23H22ClN3O2. Das durchschnittliche Gewicht des Moleküls beträgt 407,893 und das Monoisotopengewicht beträgt 407,14005467 Kaufen Sie Pagoclone.

Scientific research applications

Anxiolytic properties for panic disorder

Pagoklon, ein Cyclopyrrolon, wirkt als partieller Agonist am γ-Aminobuttersäure (GABA) A/Benzodiazepin (BDZ)-Rezeptor. Eine Studie zur Bewertung seiner Wirksamkeit als Anti-Panik-Mittel ergab vorläufige Beweise für seine anxiolytischen Eigenschaften ohne typische BDZ-Nebenwirkungen wie Sedierung, Toleranz und Entzug. Dies deutet auf einen möglichen Einsatz bei der Behandlung von Panikstörungen (DSM-IV) hin (Sandford et al., 2001).

Neuropsychological performance

The effects of pagoclone on neuropsychological performance in healthy individuals were studied and showed transient and slight negative effects on learning and memory scores at higher doses. However, these changes were not significant and disappeared on the sixth day of use, indicating a lack of behavioural toxicity (Caveney et al., 2008).

Development in panic and anxiety disorders

Pagoclone wird zur Behandlung von Panik- und Angststörungen entwickelt. Indevus startete 1996 Phase-II/III-Studien und Pfizer führte im Jahr 2000 eine Phase-III-Studie zur Behandlung von Panikstörungen durch, stellte die Entwicklung des Wirkstoffs jedoch im Jahr 2002 ein (Bateson, 2003).

Treatment of persistent developmental stuttering

In an exploratory study, pagoclone was investigated for the treatment of persistent developmental stuttering. Pagoclone was found to be effective in reducing stuttering symptoms and was well tolerated, suggesting its potential as a pharmacological treatment for stuttering (Maguire et al., 2010).

Pharmacological effects in rats

A study in rats showed that the pharmacological effects of pagoclone, such as the anxiolytic effect, are probably mediated by its main metabolite, 5′-hydroxy-pagoclone. This finding is crucial for understanding its in vivo properties (Atack et al., 2006) Buy Pagoclone.