{"id":1036,"date":"2024-06-21T05:06:46","date_gmt":"2024-06-21T05:06:46","guid":{"rendered":"https:\/\/unkrautmarkt.com\/chems\/?post_type=product&p=1036"},"modified":"2026-03-09T08:16:55","modified_gmt":"2026-03-09T08:16:55","slug":"pagoclone","status":"publish","type":"product","link":"https:\/\/chemsman.com\/en\/product-2\/pagoclone\/","title":{"rendered":"Buy Pagoclone online"},"content":{"rendered":"

Buy Pagoclone online<\/h2>\n

Description of the<\/p>\n

Buy Pagoclone<\/a>Pagoclone is an anxiolytic drug from the cyclopyrrolone family, which is related to other better-known drugs such as the sleeping pill zopiclone. It belongs to a relatively newly developed class of drugs known as non-benzodiazepines, which have similar effects to the older group of benzodiazepines but have a completely different chemical structure.<\/p>\n

Synthesis analysis<\/h3>\n

The synthesis of pagoclones involves the reaction of 2-amino-7-chloro-1,8-naphthyridine with phthalic anhydride, which leads to the corresponding phthalimide. A selective reduction of one of the imide carbonyl groups yields the corresponding alcohol.<\/a><\/p>\n

Analysing chemical reactions<\/h3>\n

Pagoklon<\/a> is a subtype-selective drug that binds primarily to the alpha2\/alpha3 subtypes of the GABAA receptor. These receptors are responsible for the anxiolytic effects of this type of medication. Chemsman<\/a><\/p>\n

Analysing physical and chemical properties<\/p>\n

Pagoclone is a small molecule with the chemical formula C23H22ClN3O2. The average weight of the molecule is 407.893 and the monoisotope weight is 407.14005467 Buy Pagoclone.<\/p>\n

Scientific research applications<\/p>\n

Anxiolytic properties for panic disorder<\/p>\n

Pagoclone, a cyclopyrrolone, acts as a partial agonist at the \u03b3-aminobutyric acid (GABA) A\/benzodiazepine (BDZ) receptor. A study evaluating its efficacy as an anti-panic agent provided preliminary evidence of its anxiolytic properties without typical BDZ side effects such as sedation, tolerance and withdrawal. This suggests a possible use in the treatment of panic disorder (DSM-IV) (Sandford et al., 2001).<\/p>\n

Neuropsychological performance<\/h3>\n

The effects of pagoclone on neuropsychological performance in healthy individuals were studied and showed transient and slight negative effects on learning and memory scores at higher doses. However, these changes were not significant and disappeared on the sixth day of use, indicating a lack of behavioural toxicity (Caveney et al., 2008).<\/p>\n

Development in panic and anxiety disorders<\/h3>\n

Pagoclone is being developed for the treatment of panic and anxiety disorders. Indevus started Phase II\/III trials in 1996 and Pfizer conducted a Phase III trial for the treatment of panic disorder in 2000, but discontinued development of the drug in 2002 (Bateson, 2003).<\/p>\n

Treatment of persistent developmental stuttering<\/h3>\n

In an exploratory study, pagoclone was investigated for the treatment of persistent developmental stuttering. Pagoclone was found to be effective in reducing stuttering symptoms and was well tolerated, suggesting its potential as a pharmacological treatment for stuttering (Maguire et al., 2010).<\/p>\n

Pharmacological effects in rats<\/h3>\n

A study in rats showed that the pharmacological effects of pagoclone, such as the anxiolytic effect, are probably mediated by its main metabolite, 5\u2032-hydroxy-pagoclone. This finding is crucial for understanding its in vivo properties (Atack et al., 2006) Buy Pagoclone.<\/p>","protected":false},"excerpt":{"rendered":"

Buy Pagoclone<\/strong><\/h3>\n
\n

Pagoclone is a powerful research chemical from the class of GABA receptor modulators. Known for its potent anxiolytic properties, Pagoclone is mainly used in scientific research. Available in high purity, ideal for precise and reliable results in your studies. Order Pagoclone safely and quickly online and benefit from a high-quality product for your research.<\/p>","protected":false},"featured_media":1849,"comment_status":"open","ping_status":"closed","template":"","meta":{"_joinchat":[]},"product_brand":[],"product_cat":[21],"product_tag":[716,706,103,698,713,710,705,703,697,700,708,699,701,709,711,718,719,717,714,715,712,111,704,707,702],"class_list":["post-1036","product","type-product","status-publish","has-post-thumbnail","product_cat-benzodiazepine","product_tag-best-cheap-price-pagoclone","product_tag-best-place-to-buy-pagoclone","product_tag-bulk-online","product_tag-buy-pagoclone","product_tag-cheap-pagoclone","product_tag-high-quality-pagoclone","product_tag-how-to-buy-pagoclone","product_tag-order-pagoclone","product_tag-pagoclone","product_tag-pagoclone-for-sale","product_tag-pagoclone-legally","product_tag-pagoclone-online","product_tag-pagoclone-pagoclone-supplier","product_tag-pagoclone-price","product_tag-pagoclone-store","product_tag-pagoclone-use","product_tag-pagoclone-wiki","product_tag-pagoclone-worldwide","product_tag-pagoclones","product_tag-purcharse-pagoclone","product_tag-shop-pagoclone","product_tag-top-quality","product_tag-where-to-buy-pagoclone","product_tag-where-to-order-pagoclone","product_tag-wholesale-pagoclone","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"\nPagoclone zu verkaufen \u2013 Pagoclone online kaufen<\/title>\n<meta name=\"description\" content=\"Pagoclone zum Verkauf in einem der besten Online-Shops, ChemsMan. Wir helfen Ihnen, hochwertiges Pagoclone online zu kaufen. Z\u00f6gern Sie nicht, Ihre Bestellung aufzugeben und profitieren Sie von den neuesten Rabatten!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/chemsman.com\/en\/product-2\/pagoclone\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pagoclone zu verkaufen \u2013 Pagoclone online kaufen\" \/>\n<meta property=\"og:description\" content=\"Pagoclone zum Verkauf in einem der besten Online-Shops, ChemsMan. Wir helfen Ihnen, hochwertiges Pagoclone online zu kaufen. Z\u00f6gern Sie nicht, Ihre Bestellung aufzugeben und profitieren Sie von den neuesten Rabatten!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/chemsman.com\/en\/product-2\/pagoclone\/\" \/>\n<meta property=\"og:site_name\" content=\"Chemsman\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-09T08:16:55+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"600\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/\",\"url\":\"https:\/\/chemsman.com\/product\/pagoclone\/\",\"name\":\"Pagoclone zu verkaufen \u2013 Pagoclone online kaufen\",\"isPartOf\":{\"@id\":\"https:\/\/chemsman.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg\",\"datePublished\":\"2024-06-21T05:06:46+00:00\",\"dateModified\":\"2026-03-09T08:16:55+00:00\",\"description\":\"Pagoclone zum Verkauf in einem der besten Online-Shops, ChemsMan. Wir helfen Ihnen, hochwertiges Pagoclone online zu kaufen. Z\u00f6gern Sie nicht, Ihre Bestellung aufzugeben und profitieren Sie von den neuesten Rabatten!\",\"breadcrumb\":{\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/#breadcrumb\"},\"inLanguage\":\"en-AU\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/chemsman.com\/product\/pagoclone\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-AU\",\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage\",\"url\":\"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg\",\"contentUrl\":\"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg\",\"width\":600,\"height\":600,\"caption\":\"Pagoclone online kaufen\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/chemsman.com\/product\/pagoclone\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/chemsman.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Shop\",\"item\":\"https:\/\/chemsman.com\/en\/shop\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Pagoclone online kaufen\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/chemsman.com\/#website\",\"url\":\"https:\/\/chemsman.com\/\",\"name\":\"Chemsman\",\"description\":\"My WordPress Blog\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/chemsman.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-AU\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Buy Pagoclone online - Pagoclone for sale @ Chemsman","description":"Get 4F-AND for sale at one of the best online shops from HelmsMan. We help you to buy 4F-ABD in high quality online. Don't hesitate to place your order and benefit from the latest discounts!","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/chemsman.com\/en\/product-2\/pagoclone\/","og_locale":"en_US","og_type":"article","og_title":"Pagoclone zu verkaufen \u2013 Pagoclone online kaufen","og_description":"Pagoclone zum Verkauf in einem der besten Online-Shops, ChemsMan. Wir helfen Ihnen, hochwertiges Pagoclone online zu kaufen. Z\u00f6gern Sie nicht, Ihre Bestellung aufzugeben und profitieren Sie von den neuesten Rabatten!","og_url":"https:\/\/chemsman.com\/en\/product-2\/pagoclone\/","og_site_name":"Chemsman","article_modified_time":"2026-03-09T08:16:55+00:00","og_image":[{"width":600,"height":600,"url":"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/chemsman.com\/product\/pagoclone\/","url":"https:\/\/chemsman.com\/product\/pagoclone\/","name":"Buy Pagoclone online - Pagoclone for sale @ Chemsman","isPartOf":{"@id":"https:\/\/chemsman.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage"},"image":{"@id":"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage"},"thumbnailUrl":"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg","datePublished":"2024-06-21T05:06:46+00:00","dateModified":"2026-03-09T08:16:55+00:00","description":"Get 4F-AND for sale at one of the best online shops from HelmsMan. We help you to buy 4F-ABD in high quality online. Don't hesitate to place your order and benefit from the latest discounts!","breadcrumb":{"@id":"https:\/\/chemsman.com\/product\/pagoclone\/#breadcrumb"},"inLanguage":"en-AU","potentialAction":[{"@type":"ReadAction","target":["https:\/\/chemsman.com\/product\/pagoclone\/"]}]},{"@type":"ImageObject","inLanguage":"en-AU","@id":"https:\/\/chemsman.com\/product\/pagoclone\/#primaryimage","url":"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg","contentUrl":"https:\/\/chemsman.com\/wp-content\/uploads\/2024\/06\/Pagoclone.jpg","width":600,"height":600,"caption":"Pagoclone online kaufen"},{"@type":"BreadcrumbList","@id":"https:\/\/chemsman.com\/product\/pagoclone\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/chemsman.com\/"},{"@type":"ListItem","position":2,"name":"Shop","item":"https:\/\/chemsman.com\/en\/shop\/"},{"@type":"ListItem","position":3,"name":"Pagoclone online kaufen"}]},{"@type":"WebSite","@id":"https:\/\/chemsman.com\/#website","url":"https:\/\/chemsman.com\/","name":"Chemsman","description":"My WordPress Blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/chemsman.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-AU"}]}},"_links":{"self":[{"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/product\/1036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/comments?post=1036"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/media\/1849"}],"wp:attachment":[{"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/media?parent=1036"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/product_brand?post=1036"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/product_cat?post=1036"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/chemsman.com\/en\/wp-json\/wp\/v2\/product_tag?post=1036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}