Opis<\/p>\n
K\u00fapi\u0165 Pagoclone<\/a>Pagoklon je liek proti \u00fazkosti v rodine cyklopyrol\u00f3nov, ktor\u00fd je pr\u00edbuzn\u00fd s in\u00fdmi zn\u00e1mej\u0161\u00edmi liekmi, ako je napr\u00edklad zopikl\u00f3n na podporu sp\u00e1nku. Patr\u00ed do relat\u00edvne novo vyvinutej skupiny liekov naz\u00fdvan\u00fdch nebenzodiazep\u00edny, ktor\u00e9 maj\u00fa podobn\u00e9 \u00fa\u010dinky ako star\u0161ia skupina benzodiazep\u00ednov, ale maj\u00fa \u00faplne in\u00fa chemick\u00fa \u0161trukt\u00faru.<\/p>\n Synt\u00e9za pagoklonov zah\u0155\u0148a reakciu 2-amino-7-chl\u00f3r-1,8-naftyrid\u00ednu s ftalanhydridom, ktor\u00e1 vedie k pr\u00edslu\u0161n\u00e9mu ftalimidu. Selekt\u00edvnou redukciou jednej z imidov\u00fdch karbonylov\u00fdch skup\u00edn sa z\u00edska pr\u00edslu\u0161n\u00fd alkohol.<\/a><\/p>\n Pagoklon<\/a> je subtypovo selekt\u00edvny liek, ktor\u00fd sa prim\u00e1rne via\u017ee na alfa2\/alfa3 podtypy GABAA receptora. Tieto receptory s\u00fa zodpovedn\u00e9 za anti-\u00fazkostn\u00e9 \u00fa\u010dinky tohto typu liekov. Chemsman<\/a><\/p>\n Anal\u00fdza fyzik\u00e1lnych a chemick\u00fdch vlastnost\u00ed<\/p>\n Pagoklon je mal\u00e1 molekula s chemick\u00fdm vzorcom C23H22ClN3O2. Priemern\u00e1 hmotnos\u0165 molekuly je 407,893 a hmotnos\u0165 monoizotopu je 407,14005467. K\u00fapi\u0165 Pagoklon.<\/p>\n Aplik\u00e1cie vedeck\u00e9ho v\u00fdskumu<\/p>\n Anxiolytick\u00e9 vlastnosti pri panickej poruche<\/p>\n Pagoklon, cyklopyrrol\u00f3n, p\u00f4sob\u00ed ako \u010diasto\u010dn\u00fd agonista na receptore \u03b3-aminomaslovej kyseliny (GABA) A\/benzodiazep\u00ednu (BDZ). \u0160t\u00fadia hodnotiaca jeho \u00fa\u010dinnos\u0165 ako antipanick\u00e9ho \u010dinidla poskytla predbe\u017en\u00e9 d\u00f4kazy o jeho anxiolytick\u00fdch vlastnostiach bez typick\u00fdch ved\u013eaj\u0161\u00edch \u00fa\u010dinkov BDZ, ako s\u00fa sed\u00e1cia, tolerancia a abstinencia. To nazna\u010duje mo\u017en\u00e9 pou\u017eitie pri lie\u010dbe panickej poruchy (DSM-IV) (Sandford et al., 2001).<\/p>\n Sk\u00famali sa \u00fa\u010dinky pagokl\u00f3nu na neuropsychologick\u00fa v\u00fdkonnos\u0165 u zdrav\u00fdch jedincov a uk\u00e1zali sa prechodn\u00e9 a mierne negat\u00edvne \u00fa\u010dinky na v\u00fdsledky u\u010denia a pam\u00e4ti pri vy\u0161\u0161\u00edch d\u00e1vkach. Tieto zmeny v\u0161ak neboli v\u00fdznamn\u00e9 a vymizli na \u0161iesty de\u0148 u\u017e\u00edvania, \u010do nazna\u010duje absenciu behavior\u00e1lnej toxicity (Caveney a kol., 2008).<\/p>\n Pagoklon sa vyv\u00edja na lie\u010dbu panick\u00fdch a \u00fazkostn\u00fdch por\u00fach. Spolo\u010dnos\u0165 Indevus za\u010dala \u0161t\u00fadie f\u00e1zy II\/III v roku 1996 a spolo\u010dnos\u0165 Pfizer uskuto\u010dnila \u0161t\u00fadiu f\u00e1zy III na lie\u010dbu panickej poruchy v roku 2000, ale v roku 2002 v\u00fdvoj lieku preru\u0161ila (Bateson, 2003).<\/p>\n V prieskumnej \u0161t\u00fadii sa sk\u00famal pagoklon na lie\u010dbu pretrv\u00e1vaj\u00facej v\u00fdvinovej koktavosti. Zistilo sa, \u017ee pagoklon je \u00fa\u010dinn\u00fd pri zni\u017eovan\u00ed sympt\u00f3mov koktavosti a je dobre tolerovan\u00fd, \u010do nazna\u010duje jeho potenci\u00e1l ako farmakologickej lie\u010dby koktavosti (Maguire a kol., 2010).<\/p>\n \u0160t\u00fadia na potkanoch uk\u00e1zala, \u017ee farmakologick\u00e9 \u00fa\u010dinky pagokl\u00f3nu, ako napr\u00edklad anxiolytick\u00fd \u00fa\u010dinok, s\u00fa pravdepodobne sprostredkovan\u00e9 jeho hlavn\u00fdm metabolitom, 5\u2032-hydroxy-pagokl\u00f3nom. Toto zistenie je k\u013e\u00fa\u010dov\u00e9 pre pochopenie jeho vlastnost\u00ed in vivo (Atack et al., 2006) K\u00fapi\u0165 pagoklon.<\/p>","protected":false},"excerpt":{"rendered":" Pagoclone je v\u00fdkonn\u00e1 v\u00fdskumn\u00e1 chemik\u00e1lia z triedy modul\u00e1torov receptorov GABA. Pagoclone, zn\u00e1my pre svoje siln\u00e9 anxiolytick\u00e9 vlastnosti, sa pou\u017e\u00edva hlavne vo vedeckom v\u00fdskume. Dostupn\u00e9 vo vysokej \u010distote, ide\u00e1lne pre presn\u00e9 a spo\u013eahliv\u00e9 v\u00fdsledky vo va\u0161ich \u0161t\u00fadi\u00e1ch. Objednajte si Pagoclone bezpe\u010dne a r\u00fdchlo online a vyu\u017eite vysokokvalitn\u00fd produkt pre svoj v\u00fdskum.<\/p>","protected":false},"featured_media":1849,"comment_status":"open","ping_status":"closed","template":"","meta":{"_joinchat":[]},"product_brand":[],"product_cat":[21],"product_tag":[716,706,103,698,713,710,705,703,697,700,708,699,701,709,711,718,719,717,714,715,712,111,704,707,702],"class_list":["post-1036","product","type-product","status-publish","has-post-thumbnail","product_cat-benzodiazepine","product_tag-best-cheap-price-pagoclone","product_tag-best-place-to-buy-pagoclone","product_tag-bulk-online","product_tag-buy-pagoclone","product_tag-cheap-pagoclone","product_tag-high-quality-pagoclone","product_tag-how-to-buy-pagoclone","product_tag-order-pagoclone","product_tag-pagoclone","product_tag-pagoclone-for-sale","product_tag-pagoclone-legally","product_tag-pagoclone-online","product_tag-pagoclone-pagoclone-supplier","product_tag-pagoclone-price","product_tag-pagoclone-store","product_tag-pagoclone-use","product_tag-pagoclone-wiki","product_tag-pagoclone-worldwide","product_tag-pagoclones","product_tag-purcharse-pagoclone","product_tag-shop-pagoclone","product_tag-top-quality","product_tag-where-to-buy-pagoclone","product_tag-where-to-order-pagoclone","product_tag-wholesale-pagoclone","first","instock","shipping-taxable","purchasable","product-type-variable"],"yoast_head":"\nAnal\u00fdza synt\u00e9zy<\/h3>\n
Anal\u00fdza chemick\u00fdch reakci\u00ed<\/h3>\n
Neuropsychologick\u00fd v\u00fdkon<\/h3>\n
V\u00fdvoj pri panick\u00fdch a \u00fazkostn\u00fdch poruch\u00e1ch<\/h3>\n
Lie\u010dba pretrv\u00e1vaj\u00facej v\u00fdvinovej koktavosti<\/h3>\n
Farmakologick\u00e9 \u00fa\u010dinky na potkanoch<\/h3>\n
Pagoclone kaufen<\/strong><\/h3>\n
\n